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New possibilities for DAO delivery with AB Biotek’s HNH microencapsulated ingredient

The ingredient supplier has launched adiDAO microencapsulated; DAO surrounded by two food-grade protective layers produced using a combination of coating technologies, designed to protect the DAO.

“We developed protective layers to ensure they remain resistant until they reach the targeted area in the intestine,” explained Jordi Cuñé, R&D Manager, AB Biotek HNH. “These layers dissolve naturally in the body, releasing the DAO enzyme exactly where it’s needed.”

The layers also help to prevent against undesirable interactions with other bioactive ingredients.

The DAO issue

Increased levels of unmetabolized histamine in the blood stream can result in gastro-intestinal issues, skin conditions, lower urinary tract (LUTS) symptoms, fibromyalgia, migraine and attention deficit hyperactivity disorder (ADHD).

Recent research​, spotlighted by the firm, has suggested a connection between DAO enzyme deficiency and comorbidities and cognitive dysfunction in children and adolescents with ADHD.

DAO helps the body to break down dietary histamine, yet DAO deficiency is one of the world’s most common enzyme-related metabolic disorders.

There is growing interest in solutions that enhance histamine degradation by increasing levels of DAO in the gut. However, DAO is sensitive to stomach pH, necessitating the use of delivery mechanisms that are gastro-resistant.

In addition, DAO tends to interact with other bioactive ingredients in a way that diminishes its benefits.

Microencapsulation benefits​​

The technology will offer new opportunities for developing innovative products in both the pharmaceutical and nutraceutical spaces. For example, it will enable manufacturers to include DAO in anti-histamine and ADHD treatments, or to combine it with probiotics or prebiotics in supplements.

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Written by The Muscle Mag

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