The Muscle Mag
Data published in Molecular Nutrition and Food Research indicated that consuming a 50 gram dose of Palatinose one hour before a mixed meal test resulted in significantly higher increases in glucagon-like peptide (GLP-1) and peptide YY (PYY) levels compared to rapidly digested sucrose. This suggests that this carbohydrate may have positive effects on key metabolic parameters crucial for maintaining a healthy body weight, blood glucose levels, and cardiovascular health.
Dr. Stephan Theis, the head of nutrition science at Beneo and co-author of the study, expressed enthusiasm for the research on metabolism-regulating gut hormones and its potential applications in clinical nutrition and meal replacement. The study focused on older, overweight, and obese individuals, with or without diabetes mellitus, making its findings relevant to a large portion of the population.
The study supported the idea that Palatinose can enhance metabolic health, particularly by increasing the secretion of GLP-1. This slow-release carbohydrate has shown effectiveness in product development for managing weight and blood glucose levels.
GLP-1 plays a key role in metabolism, including appetite reduction, which can contribute to weight loss. The study’s findings suggest that Palatinose may boost the body’s natural production of GLP-1, offering potential health benefits.
Palatinose, produced from the rearrangement of the glycosidic bond in sucrose, provides balanced carbohydrate energy with a low glycemic index. Its slow-release properties promote the release of GLP-1 in the lower parts of the small intestine, as stated by Beneo.
Study details
Using a double-blind, randomized, placebo-controlled, cross-over design, the study involved 30 overweight/obese participants aged between 49 and 77 (including 15 with type 2 diabetes). After consuming breakfast, participants received either 50 grams of isomaltulose or sucrose as a snack one hour before lunch. The results revealed higher levels of GLP-1 with isomaltulose compared to sucrose.
Prof. Andreas Pfeiffer from Charité – Universitätsmedizin Berlin led the researchers and noted that the robust release of gut hormones with Palatinose was not concealed by subsequent meals, a novel finding in the study.
The study, supported by Beneo, concluded that isomaltulose stimulates the release of GLP-1 and GIP more effectively than sucrose, potentially explaining the increased insulin secretion observed in participants with type 2 diabetes. The research also highlighted the difference in GLP-1 responses between controls and type 2 diabetes patients.
Source: Molecular Nutrition and Food Research
2024, Volume 68, Issue 4:e2300086, doi: 10.1002/mnfr.202300086
“Isomaltulose Enhances GLP-1 and PYY Secretion to a Mixed Meal in People With or Without Type 2 Diabetes as Compared to Saccharose”
Authors: J. Zhang et al.
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