The Muscle Mag
Ildong Bioscience Co.’s B. lactis IDCC 4301, known as B. lactis Fit, was found to improve serum triglyceride levels, as reported in Food & Function.
Scientists from Kyung Hee University, Ildong Bioscience, and Dongguk University conducted a trial where they observed anti-obesity effects in obese women after 12 weeks of B. lactis IDCC 4301 supplementation. The probiotics group experienced a 2.6 times decrease in total fat mass and a 7 times decrease in trunk fat mass compared to the placebo group. Postmenopausal women showed even greater results, with a 38% difference in total fat mass change compared to all women.
Funded by Ildong Bioscience Co., Ltd., this study highlights the association between B. lactis IDCC 4301 and body fat loss, particularly in terms of serum triglyceride and adipokine levels.
Gut microbiota and obesity
The link between gut microbiota and obesity was first established by Jeffrey Gordon and his team at Washington University in St. Louis in 2006. Their research showed that microbial populations differ between obese and lean individuals, and that weight loss in obese people led to a change in their gut microflora back to that of lean individuals. This indicated a microbial component in obesity (Nature, Vol. 444, pp. 1022-1023, 1027-1031).
A study in Science (Vol. 341, Issue 6150) by Professor Gordon also demonstrated that transplanting gut bacteria from obese humans to germ-free mice resulted in more weight gain and fat accumulation compared to mice given bacteria from lean individuals.
Research suggests that the microbiota in the gut plays a significant role in weight management, prompting investigations into the potential of probiotics in weight control.
The study on B. lactis IDCC 4301, a probiotic strain derived from breastfed infants’ feces, highlights its potential contributions to weight management as it was a finalist in the Weight Management Ingredient of the Year category at the 2023 NutraIngredients-Asia Awards.
Study details
Ninety-nine obese women with an average age of 53.5 participated in a randomized, double-blind, placebo-controlled study where they were given at least five billion CFUs per day of B. lactis Fit or a placebo for 12 weeks. Results indicated a significant decrease in total fat levels, trunk fat, and serum triglyceride concentration in the probiotic group compared to the placebo group, especially in postmenopausal women.
The study concluded that B. lactis IDCC 4301 could aid in body fat loss and improve metabolic health parameters in obese women.
Source: Food & Function
2024, Volume 15, Pages 8448-8458, doi: 10.1039/D4FO00535J
“Bifidobacterium lactis IDCC 4301 (B. lactis Fit™) supplementation effects on body fat, serum triglyceride, and adipokine ratio in obese women: a randomized clinical trial”
Authors: M. Lee et al.
