The Muscle Mag
According to a study published in the journal Sports, scientists from Mexico have found that taking daily doses of 400 mg may have a performance-enhancing effect in men who are trained in resistance exercises. The study also concluded that a 12-week supplementation at this dose is safe for healthy adults.
TSI, the company that markets the Peak ATP ingredient (Adenosine 5’-Triphosphate (ATP) disodium), expressed their satisfaction with the new paper. The Peak ATP ingredient was prominently featured in the human clinical studies included in the analysis.
Shawn Baier, the vice president of business development for TSI’s innovative products division, stated, “We are pleased to have the scientific community validate the importance and quality of our research. This meta-analysis comes at a time when there is a growing interest in PEAK ATP, as more brands worldwide are seeking to offer their customers the best pre-workout ingredient for real energy and results. Many studies have shown its immediate benefits for athletes, weekend warriors, and regular exercisers.”
Energy
ATP serves as the energy source for tissues, but it is also believed to have functions beyond just energy production.
Although ATP is known to directly impact muscle contraction, relaxation, and signaling for other effects, there is controversy in the scientific literature regarding its ability to enhance physical performance.
The authors of the study, associated with the Autonomous University of Yucatan, the Autonomous University of Nuevo Leon, and the Regional High Specialty Hospital of the Yucatan, explained, “One of the reasons for this controversy is that oral ATP supplementation does not lead to an increase in intramuscular concentrations. Additionally, most studies do not measure plasma levels of ATP and its metabolites after supplementation, making it challenging to link improvements in physical performance and body composition to supplementation.”
Moreover, the data is also complicated by the use of different doses and co-supplementation with other substances.
Therefore, the review and meta-analysis aimed to assess the impact of oral ATP supplementation on various anaerobic variables in individuals trained in resistance exercises.
Study Details
By focusing on recent studies published between 2000 and 2022, the researchers identified five double-blind, randomized controlled trials meeting their criteria, involving a total of 121 adult men.
The analysis revealed that oral ATP supplementation significantly improved maximal strength compared to a placebo. However, there were no significant differences in the maximum number of repetitions or maximum anaerobic power between the ATP group and the placebo group.
The researchers noted, “We found that significant improvements were seen in the ATP group with doses starting from 225 mg/day, and at 400 mg/day, significant improvements were observed compared to the placebo group. Therefore, the ATP dosage appears to be crucial in achieving performance-enhancing effects.”
TSI’s Baier added, “As more consumers seek non-stimulant energy options to enhance their peak performance, science supports the significant benefits that can be gained by using PEAK ATP in conjunction with exercise.”
Source: Sports
2024, 12(3), 82; doi: 10.3390/sports12030082
“The Effect of Oral Adenosine Triphosphate (ATP) Supplementation on Anaerobic Exercise in Healthy Resistance-Trained Individuals: A Systematic Review and Meta-Analysis”
Authors: R. González-Marenco et al.
