CK Ingredients, a Canadian raw materials supplier, has expanded its partnership with Tradichem, a Spanish nutraceutical company known for developing H20Slim. This partnership now allows U.S. manufacturers to access the ingredient for calorie control.
“There’s a lot of talk about weight management in our society,” said Colleen Madden, vice president of innovation at CK Ingredients. She mentioned the shift in focus towards glucose management which has been influenced by products like ‘Ozempic’.

Despite the popularity of GLP-1 agonists, Madden appreciates nutraceutical companies like Tradichem that are exploring simpler physical mechanisms behind natural weight management solutions, such as H20Slim.
According to Madden, this approach offers consumers a more accessible path towards achieving their weight management goals.
How it works
Tradichem extracted polysaccharides from the Agaricus bisporus mushroom used in H20Slim. These polysaccharides have lipid-trapping properties when they come in contact with water. Tradichem claims that this process results in a harmless cationic polymer that can trap up to 80% of consumed fat through physical and electrostatic forces, expelling the fat from the body.
A 12-week double-blind study published in the American Journal of Biomedical Science and Research in 2020 showed that the polysaccharides in the mushroom had a direct impact on weight loss and waist circumference.
Furthermore, the study suggested that the fat-trapping properties of these polysaccharides are likely linked to the observed weight loss effects.
Consumers are advised to wait five minutes before eating a meal after ingesting an H20Slim product. Madden recommends using these products with caution, particularly focusing on reducing intake of unhealthy fats rather than healthy fats.
“There are several unique aspects to H2OSlim as an ingredient,” explained José Ángel Marañón, PhD, and executive vice president of Tradichem, highlighting the importance of the soil quality for cultivating the Agaricus bisporus mushroom.
Marañón emphasized that the high concentration of water-soluble polysaccharides in H20Slim is directly tied to the European soil where the mushroom is grown.
U.S. Consumers
H20Slim was first launched in Europe in 2018 and later expanded to the Asian market during the COVID-19 pandemic. It is currently available in China, Taiwan, and Thailand.
By 2020, Tradichem had introduced various blends of H20Slim including H2OSlim Forte, H20Slim Carb, H20Slim Digest, and H20Slim Detox, catering to different weight management needs from blocking excessive carb intake to regulating satiation levels.
“We have higher expectations for the U.S. market compared to Europe,” Marañón stated. “We believe the U.S. market is more receptive to science-based ingredients like H20Slim.”
Source: American Journal of Biomedical Science and Research
doi: 10.34297/AJBSR.2020.07.001205
“H2Oslim, the water-soluble polysaccharides from Agaricus bisporus, significantly reduces body weight and improves lipid parameters in overweight humans in a randomized double-blind vs placebo study”
Authors: Gemma Clemente-Ramos et al.